Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.

Nasto, L. A., Ngo, K., Leme, A., Robinson, A., Dong, Q., Roughley, P., Usas, A., Sowa, G., Pola, E., Kang, J., Niedernhofer, L., Shapiro, S., Vo, N., Investigating the role of DNA damage in tobacco smoking-induced spine degeneration, <<THE SPINE JOURNAL>>, 2013; (Novembre): 1529-1532. [doi:10.1016/j.spinee.2013.08.034] [http://hdl.handle.net/10807/51970]

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Nasto, Luigi Aurelio;Pola, Enrico;
2013

Abstract

Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
2013
Inglese
Nasto, L. A., Ngo, K., Leme, A., Robinson, A., Dong, Q., Roughley, P., Usas, A., Sowa, G., Pola, E., Kang, J., Niedernhofer, L., Shapiro, S., Vo, N., Investigating the role of DNA damage in tobacco smoking-induced spine degeneration, <<THE SPINE JOURNAL>>, 2013; (Novembre): 1529-1532. [doi:10.1016/j.spinee.2013.08.034] [http://hdl.handle.net/10807/51970]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/51970
Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 57
social impact