Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.

Nasto, L. A., Ngo, K., Leme, A., Robinson, A., Dong, Q., Roughley, P., Usas, A., Sowa, G., Pola, E., Kang, J., Niedernhofer, L., Shapiro, S., Vo, N., Investigating the role of DNA damage in tobacco smoking-induced spine degeneration, <<THE SPINE JOURNAL>>, 2013; (Novembre): 1529-1532. [doi:10.1016/j.spinee.2013.08.034] [http://hdl.handle.net/10807/51970]

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Nasto, Luigi Aurelio;Pola, Enrico;
2013

Abstract

Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
Inglese
Nasto, L. A., Ngo, K., Leme, A., Robinson, A., Dong, Q., Roughley, P., Usas, A., Sowa, G., Pola, E., Kang, J., Niedernhofer, L., Shapiro, S., Vo, N., Investigating the role of DNA damage in tobacco smoking-induced spine degeneration, <<THE SPINE JOURNAL>>, 2013; (Novembre): 1529-1532. [doi:10.1016/j.spinee.2013.08.034] [http://hdl.handle.net/10807/51970]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/51970
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