Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.

Lopetuso, L., Petito, V., Cufino, V., Arena, V., Stigliano, E., Gerardi, V., Gaetani, E., Poscia, A., Amato, A., Cammarota, G., Papa, A., Sgambato, A., Gasbarrini, A., Scaldaferri, F., Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice, <<DIGESTIVE AND LIVER DISEASE>>, 2013; 45 (12): 1017-1021. [doi:10.1016/j.dld.2013.06.007] [http://hdl.handle.net/10807/51413]

Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice

Cufino, Valerio;Arena, Vincenzo;Stigliano, Egidio;Gerardi, Viviana;Gaetani, Eleonora;Poscia, Andrea;Amato, Arianna;Cammarota, Giovanni;Papa, Alfredo;Sgambato, Alessandro;Gasbarrini, Antonio;Scaldaferri, Franco
2013

Abstract

Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.
Inglese
Lopetuso, L., Petito, V., Cufino, V., Arena, V., Stigliano, E., Gerardi, V., Gaetani, E., Poscia, A., Amato, A., Cammarota, G., Papa, A., Sgambato, A., Gasbarrini, A., Scaldaferri, F., Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice, <>, 2013; 45 (12): 1017-1021. [doi:10.1016/j.dld.2013.06.007] [http://hdl.handle.net/10807/51413]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/51413
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