Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.
Romani, F., Tropea, A., Scarinci, E., Dello Russo, C., Lisi, L., Catino, S., Lanzone, A., Apa, R., Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function., <<JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS>>, 2013; 31 (2): 170-180. [doi:10.1080/10590501.2013.782180] [http://hdl.handle.net/10807/51248]
Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function.
Romani, Federica;Tropea, Anna;Scarinci, Elisa;Dello Russo, Cinzia;Lisi, Lucia;Lanzone, Antonio;Apa, Rosanna
2013
Abstract
Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.
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