The antiphospholipid syndrome (APS) is a disease discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of APS morbidity and experimental data support the activation of complement cascade as a pivotal event in its physiopathology. In this review we will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis and we will point up the clinical significance of this novel finding.
De Carolis, S., Vitucci, A., Garofalo, S., Salvi, S., Del Sordo, G., Rella, R., Botta, A., ROLE OF COMPLEMENT IN PREGNANCY WITH ANTIPHOSPHOLIPID SYNDROME: MECHANISMS OF PATHOGENESIS AND CLINICAL ASPECTS., <<INTERNATIONAL JOURNAL OF CLINICAL RHEUMATOLOGY>>, 2013; 2013 (Giugno): 399-405 [http://hdl.handle.net/10807/50769]
ROLE OF COMPLEMENT IN PREGNANCY WITH ANTIPHOSPHOLIPID SYNDROME: MECHANISMS OF PATHOGENESIS AND CLINICAL ASPECTS.
De Carolis, Sara;Garofalo, Serafina;Salvi, Silvia;Del Sordo, Gelsomina;Rella, Rossella;Botta, Angela
2013
Abstract
The antiphospholipid syndrome (APS) is a disease discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of APS morbidity and experimental data support the activation of complement cascade as a pivotal event in its physiopathology. In this review we will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis and we will point up the clinical significance of this novel finding.
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