Invasive fungal Infections (IFIs) represent important complications in patients with haematological malignancies. Chemoprevention of IFIs may play an important role in this setting, but in the past decades the majority of antifungal drugs utilized demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. The new triazoles are a very useful antifungal drugs, more suitable for prophylaxis of IFIs than amphotericin B and echinocandins. In this review the main clinical data about antifungal prophylaxis with fluconazole, itraconazole, voriconazole and posaconazole are analyzed. At present posaconazole was appears to be the most efficacious azole in antifungal prophylaxis, particularly in patients with acute myeloid leukaemia.

Pagano, L., Caira, M., The role of primary antifungal prophylaxis in patients with haematological malignancies, <<CLINICAL MICROBIOLOGY AND INFECTION>>, 2014; 20 (6): 19-26. [doi:10.1111/1469-0691.12464] [http://hdl.handle.net/10807/50416]

The role of primary antifungal prophylaxis in patients with haematological malignancies

Pagano, Livio;
2014

Abstract

Invasive fungal Infections (IFIs) represent important complications in patients with haematological malignancies. Chemoprevention of IFIs may play an important role in this setting, but in the past decades the majority of antifungal drugs utilized demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. The new triazoles are a very useful antifungal drugs, more suitable for prophylaxis of IFIs than amphotericin B and echinocandins. In this review the main clinical data about antifungal prophylaxis with fluconazole, itraconazole, voriconazole and posaconazole are analyzed. At present posaconazole was appears to be the most efficacious azole in antifungal prophylaxis, particularly in patients with acute myeloid leukaemia.
2014
Inglese
Pagano, L., Caira, M., The role of primary antifungal prophylaxis in patients with haematological malignancies, <<CLINICAL MICROBIOLOGY AND INFECTION>>, 2014; 20 (6): 19-26. [doi:10.1111/1469-0691.12464] [http://hdl.handle.net/10807/50416]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/50416
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 18
social impact