BACKGROUND/AIMS: Sorafenib has become the standard first-line treatment for patients with advanced HCC and acts by inducing alterations in tumor vascularity. We wanted to evaluate the feasibility of dynamic CEUS (D-CEUS) as a predictor of early tumor response to Sorafenib and to correlate functional parameters with clinical efficacy endpoints. METHODS: Twenty-eight HCC patients treated with Sorafenib 400 mg bid were prospectively enrolled. CEUS was performed at baseline (T0) and after 15 (T1) and 30 (T2) days of treatment. Tumor vasculature was assessed in a specific harmonic mode associated with a perfusion and quantification software (Q-Lab, Philips). Variations between T1/T2 and T0 were calculated for five D-CEUS functional parameters (peak intensity, PI; time to PI, TP; area under the curve, AUC; slope of wash in, Pw; mean transit time, MTT) and were compared for responders and non responders. The correlation between D-CEUS parameters, overall survival (OS) and progression free survival (PFS) was also assessed. A p value < 0.05 was considered statistically significant. RESULTS: The percentage variation at T1 significantly correlated with response in three D-CEUS parameters (AUC, PI and Pw; p = 0.002, <0.001 and 0.003 respectively). A decrease of AUC (p= 0.045) and an increased/unchanged value of TP (p=0.029) and MTT (p=0.010) were associated with longer survival. Three D-CEUS parameters (AUC, TP, Pw) were significantly associated with PFS. CONCLUSION: D-CEUS provides a reliable and early measure of efficacy for anti-angiogenic therapies and could be an excellent tool for selecting patients who will benefit from treatment.

Zocco, M. A., Garcovich, M., Lupascu, A., Di Stasio, E., Roccarina, D., Annicchiarico, B. E., Riccardi, L., Ainora, M. E., Ponziani, F. R., Caracciolo, G., Rapaccini, G. L., Landolfi, R., Siciliano, M., Pompili, M., Gasbarrini, A., Early prediction of response to Sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound, <<JOURNAL OF HEPATOLOGY>>, N/A; (N/A): N/A-N/A. [doi:10.1016/j.jhep.2013.06.011] [http://hdl.handle.net/10807/45656]

Early prediction of response to Sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound

Zocco, Maria Assunta;Garcovich, Matteo;Lupascu, Andrea;Di Stasio, Enrico;Roccarina, Davide;Annicchiarico, Brigida Eleonora;Riccardi, Laura;Ainora, Maria Elena;Ponziani, Francesca Romana;Caracciolo, Gianluigi;Rapaccini, Gian Ludovico;Landolfi, Raffaele;Siciliano, Massimo;Pompili, Maurizio;Gasbarrini, Antonio
2013

Abstract

BACKGROUND/AIMS: Sorafenib has become the standard first-line treatment for patients with advanced HCC and acts by inducing alterations in tumor vascularity. We wanted to evaluate the feasibility of dynamic CEUS (D-CEUS) as a predictor of early tumor response to Sorafenib and to correlate functional parameters with clinical efficacy endpoints. METHODS: Twenty-eight HCC patients treated with Sorafenib 400 mg bid were prospectively enrolled. CEUS was performed at baseline (T0) and after 15 (T1) and 30 (T2) days of treatment. Tumor vasculature was assessed in a specific harmonic mode associated with a perfusion and quantification software (Q-Lab, Philips). Variations between T1/T2 and T0 were calculated for five D-CEUS functional parameters (peak intensity, PI; time to PI, TP; area under the curve, AUC; slope of wash in, Pw; mean transit time, MTT) and were compared for responders and non responders. The correlation between D-CEUS parameters, overall survival (OS) and progression free survival (PFS) was also assessed. A p value < 0.05 was considered statistically significant. RESULTS: The percentage variation at T1 significantly correlated with response in three D-CEUS parameters (AUC, PI and Pw; p = 0.002, <0.001 and 0.003 respectively). A decrease of AUC (p= 0.045) and an increased/unchanged value of TP (p=0.029) and MTT (p=0.010) were associated with longer survival. Three D-CEUS parameters (AUC, TP, Pw) were significantly associated with PFS. CONCLUSION: D-CEUS provides a reliable and early measure of efficacy for anti-angiogenic therapies and could be an excellent tool for selecting patients who will benefit from treatment.
Inglese
Zocco, M. A., Garcovich, M., Lupascu, A., Di Stasio, E., Roccarina, D., Annicchiarico, B. E., Riccardi, L., Ainora, M. E., Ponziani, F. R., Caracciolo, G., Rapaccini, G. L., Landolfi, R., Siciliano, M., Pompili, M., Gasbarrini, A., Early prediction of response to Sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound, <<JOURNAL OF HEPATOLOGY>>, N/A; (N/A): N/A-N/A. [doi:10.1016/j.jhep.2013.06.011] [http://hdl.handle.net/10807/45656]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/45656
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 61
  • ???jsp.display-item.citation.isi??? ND
social impact