Immune reconstitution inflammatory syndrome (IRIS) is a recently described syndrome among human immunodeficiency virus (HIV)-infected patients attributable to the recovery of the immune system during antiretroviral therapy. A growing number of researches on this syndrome have been conducted in recent years, but IRIS in children has not been widely studied. We report the case of a 4.5 month-old, tuberculosis (TB)-HIV co-infected girl who developed IRIS two months after beginning antiretroviral and anti-TB medications. We moreover review the immunopathogenesis of TB-HIV coinfection and IRIS, with particular regard to TB-related IRIS.
Buonsenso, D., Pirronti, T., Genovese, O., Gargiullo, L., Ranno, O. G., Valentini, P., “Side effects of the immunesystem: lessons from tuberculosis-related immune reconstitution inflammatory syndrome”., <<EUROPEAN JOURNAL OF INFLAMMATION>>, 2012; (10 (1)): 1-10 [http://hdl.handle.net/10807/43398]
“Side effects of the immunesystem: lessons from tuberculosis-related immune reconstitution inflammatory syndrome”.
Buonsenso, Danilo;Pirronti, Tommaso;Genovese, Orazio;Ranno, Orazio Gaetano;Valentini, Piero
2012
Abstract
Immune reconstitution inflammatory syndrome (IRIS) is a recently described syndrome among human immunodeficiency virus (HIV)-infected patients attributable to the recovery of the immune system during antiretroviral therapy. A growing number of researches on this syndrome have been conducted in recent years, but IRIS in children has not been widely studied. We report the case of a 4.5 month-old, tuberculosis (TB)-HIV co-infected girl who developed IRIS two months after beginning antiretroviral and anti-TB medications. We moreover review the immunopathogenesis of TB-HIV coinfection and IRIS, with particular regard to TB-related IRIS.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
