Objective The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC). Methods We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two consecutive occasions, to allow the calculation of the DT. The influence of DT and other clinical and pathological variables on tumor recurrence and patient survival was determined by the Kaplan–Meier method and uni- and multivariate analysis. Results Median overall survival was 40 months; 1-, 3-, and 5-year survival rates were 86.1, 55.1, and 35.1 %, respectively. Median disease-free survival was 17 months; 1-, 3-, and 5-year disease-free survival rates were 62.0, 29.1, and 23.3 %, respectively. At univariate analysis, DT <70 days (p<0.001) and advanced tumor stage (p=0.024) were associated with worse overall survival and maintained significance at multivariate analysis. Conclusions DT is a clinically useful parameter to estimate the prognosis of “mass-forming” IHC in patients undergoing liver resection.

De Rose, A. M., Cucchetti, A., Clemente, G., Ardito, F., Giovannini, I., Ercolani, G., Giuliante, F., Pinna, A., Nuzzo, G., Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma., <<JOURNAL OF GASTROINTESTINAL SURGERY>>, 2013; 17 (4): 739-747. [doi:10.1007/s11605-012-2129-6] [http://hdl.handle.net/10807/43124]

Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma.

De Rose, Agostino Maria;Clemente, Gennaro;Ardito, Francesco;Giovannini, Ivo;Giuliante, Felice;Nuzzo, Gennaro
2013

Abstract

Objective The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC). Methods We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two consecutive occasions, to allow the calculation of the DT. The influence of DT and other clinical and pathological variables on tumor recurrence and patient survival was determined by the Kaplan–Meier method and uni- and multivariate analysis. Results Median overall survival was 40 months; 1-, 3-, and 5-year survival rates were 86.1, 55.1, and 35.1 %, respectively. Median disease-free survival was 17 months; 1-, 3-, and 5-year disease-free survival rates were 62.0, 29.1, and 23.3 %, respectively. At univariate analysis, DT <70 days (p<0.001) and advanced tumor stage (p=0.024) were associated with worse overall survival and maintained significance at multivariate analysis. Conclusions DT is a clinically useful parameter to estimate the prognosis of “mass-forming” IHC in patients undergoing liver resection.
Inglese
De Rose, A. M., Cucchetti, A., Clemente, G., Ardito, F., Giovannini, I., Ercolani, G., Giuliante, F., Pinna, A., Nuzzo, G., Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma., <<JOURNAL OF GASTROINTESTINAL SURGERY>>, 2013; 17 (4): 739-747. [doi:10.1007/s11605-012-2129-6] [http://hdl.handle.net/10807/43124]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/43124
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