The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.
Paolini, F., Carbone, A., Benevolo, M., Silipo, V., Rollo, F., Covello, R., Piemonte, P., Frascione, P., Capizzi, R., Catricalà, C., Venuti, A., Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma, <<JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH>>, 2011; 30 (Novembre): N/A-N/A. [doi:10.1186/1756-9966-30-108] [http://hdl.handle.net/10807/42264]
Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma
Carbone, Angelo;Capizzi, Rodolfo;
2011
Abstract
The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.
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