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EnglishDC deliver information regulating trafficking of effector T cells along T-cell priming. However, the role of pathogen-derived motives in the regulation of movement of T cells has not been studied. We hereinafter report that amount of M tuberculosis in the adjuvant modulates relocation of PLP139-151 specific T cells. In the presence of a low dose of M tuberculosis in the adjuvant, T cells (detected by CDR3 BV-BJ spectratyping, the so-called "immunoscope") mostly reach the spleen by day 28 after immunization ("late relocation") in the SJL strain, whereas T cells reach the spleen by d 14 with a high dose of M tuberculosis ("early relocation"). The C57Bl/6 background confers a dominant "early relocation" phenotype to F1 (SJL×C57Bl/6) mice, allowing early relocation of T cells in the presence of low dose M tuberculosis. A single non-synonymous polymorphism of TLR2 is responsible for "early/late" relocation phenotype. Egress of T lymphocytes is regulated by TLR2 expressed on T cells. Thus, pathogens engaging TLR2 on T cells regulate directly T-cell trafficking, and polymorphisms of TLR2 condition T-cell trafficking upon a limiting concentration of ligand.
Nicolò, C., Di Sante, G., Procoli, A., Migliara, G., Piermattei, A., Valentini, M., Delogu, G., Cittadini, A., Constantin, G., Ria, F., M tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2, <<PLOS ONE>>, 2013; 8 (2): e55819-e55819. [doi:10.1371/journal.pone.0055819] [http://hdl.handle.net/10807/42093]
| Autori: | ||
| Titolo: | M tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1371/journal.pone.0055819 | |
| Data di pubblicazione: | 2013 | |
| Abstract: | DC deliver information regulating trafficking of effector T cells along T-cell priming. However, the role of pathogen-derived motives in the regulation of movement of T cells has not been studied. We hereinafter report that amount of M tuberculosis in the adjuvant modulates relocation of PLP139-151 specific T cells. In the presence of a low dose of M tuberculosis in the adjuvant, T cells (detected by CDR3 BV-BJ spectratyping, the so-called "immunoscope") mostly reach the spleen by day 28 after immunization ("late relocation") in the SJL strain, whereas T cells reach the spleen by d 14 with a high dose of M tuberculosis ("early relocation"). The C57Bl/6 background confers a dominant "early relocation" phenotype to F1 (SJL×C57Bl/6) mice, allowing early relocation of T cells in the presence of low dose M tuberculosis. A single non-synonymous polymorphism of TLR2 is responsible for "early/late" relocation phenotype. Egress of T lymphocytes is regulated by TLR2 expressed on T cells. Thus, pathogens engaging TLR2 on T cells regulate directly T-cell trafficking, and polymorphisms of TLR2 condition T-cell trafficking upon a limiting concentration of ligand. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Nicolò, C., Di Sante, G., Procoli, A., Migliara, G., Piermattei, A., Valentini, M., Delogu, G., Cittadini, A., Constantin, G., Ria, F., M tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2, <<PLOS ONE>>, 2013; 8 (2): e55819-e55819. [doi:10.1371/journal.pone.0055819] [http://hdl.handle.net/10807/42093] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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