Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. Whileow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated by thalamo-reticular and thalamo-cortical circuits. In a recent high-density EEG study, the authors found that 18 medicated schizophrenia patients had reduced sleep spindles, compared with healthy and depressed subjects, during the first non-REM episode. In the present study, the authors investigated whether spindle deficits were present in a larger sample of schizophrenia patients, were consistent across the night, were related to antipsychotic medications, and were suggestive of impairments in specific neuronal circuits.

Ferrarelli, F., Peterson, M., Sarasso, S., Riedner, B., Murphy, M., Benca, R., Bria, P., Kalin, N., Tononi, G., Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles., <<Am J Psychiatry.>>, 2010; 167 (11): 1339-1348. [doi:10.1176/appi.ajp.2010.09121731] [http://hdl.handle.net/10807/41656]

Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles.

Ferrarelli, Fabio;Bria, Pietro;
2010

Abstract

Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. Whileow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated by thalamo-reticular and thalamo-cortical circuits. In a recent high-density EEG study, the authors found that 18 medicated schizophrenia patients had reduced sleep spindles, compared with healthy and depressed subjects, during the first non-REM episode. In the present study, the authors investigated whether spindle deficits were present in a larger sample of schizophrenia patients, were consistent across the night, were related to antipsychotic medications, and were suggestive of impairments in specific neuronal circuits.
eng
Ferrarelli, F., Peterson, M., Sarasso, S., Riedner, B., Murphy, M., Benca, R., Bria, P., Kalin, N., Tononi, G., Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles., <>, 2010; 167 (11): 1339-1348. [doi:10.1176/appi.ajp.2010.09121731] [http://hdl.handle.net/10807/41656]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/41656
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