PURPOSE: To prospectively assess the technical feasibility and reproducibility of quantitative foot perfusion multidetector-row computed tomography (MDCT) in patients with peripheral occlusive artery disease (PAOD) and to evaluate perfusion parameters changes after endovascular treatment. MATERIALS AND METHODS: Institutional review board approval and informed patient consent were obtained. 10 patients older than 65 years (mean 74.1 years, range 66-95 years) with PAOD and who were referred to our department for single-limb endovascular treatment were enrolled prospectively. All patients underwent foot CT perfusion examinations before and within 72h after endovascular treatment. A 64-row CT lightspeed VCT scanner (GE Medical Systems) was used with acquisition of eight contiguous 5-mm reconstructed sections (60-s acquisition time; 40mL Iomeprol 400mgI/mL, @4mL/s). Data were analyzed by two blinded readers using commercially available software to calculate perfusion parameters. Inter-observer and intra-observer agreement of perfusion CT analysis was assessed using Bland-Altman analyses and intra-class correlation coefficient (ICC). Changes in perfusion parameters after endovascular treatment were assessed using Wilcoxon's test. RESULTS: Good inter-observer and intra-observer agreement was obtained in all patients. Good agreement was obtained for perfusion parameters for the untreated foot and in repeated studies. By comparing perfusion parameters in the treated foot, a significantly shorter mean transit time (MTT) was obtained. CONCLUSIONS: Foot CT perfusion is a feasible and reproducible technique. A significant decrease of MTT between pre- and post-revascularization suggests improved flow in the below-the-knee arteries.

Iezzi, R., Santoro, M., Dattesi, R., La Torre, M. F., Tinelli, G., Snider, F., Bonomo, L., Foot CT perfusion in patients with peripheral arterial occlusive disease (PAOD): A feasibility study, <<EUROPEAN JOURNAL OF RADIOLOGY>>, 2013; (Marzo): N/A-N/A. [doi:10.1016/j.ejrad.2012.12.021] [http://hdl.handle.net/10807/41605]

Foot CT perfusion in patients with peripheral arterial occlusive disease (PAOD): A feasibility study

Iezzi, Roberto;Santoro, Marco;Dattesi, Roberta;La Torre, Michele Fabio;Tinelli, Giovanni;Snider, Francesco;Bonomo, Lorenzo
2013

Abstract

PURPOSE: To prospectively assess the technical feasibility and reproducibility of quantitative foot perfusion multidetector-row computed tomography (MDCT) in patients with peripheral occlusive artery disease (PAOD) and to evaluate perfusion parameters changes after endovascular treatment. MATERIALS AND METHODS: Institutional review board approval and informed patient consent were obtained. 10 patients older than 65 years (mean 74.1 years, range 66-95 years) with PAOD and who were referred to our department for single-limb endovascular treatment were enrolled prospectively. All patients underwent foot CT perfusion examinations before and within 72h after endovascular treatment. A 64-row CT lightspeed VCT scanner (GE Medical Systems) was used with acquisition of eight contiguous 5-mm reconstructed sections (60-s acquisition time; 40mL Iomeprol 400mgI/mL, @4mL/s). Data were analyzed by two blinded readers using commercially available software to calculate perfusion parameters. Inter-observer and intra-observer agreement of perfusion CT analysis was assessed using Bland-Altman analyses and intra-class correlation coefficient (ICC). Changes in perfusion parameters after endovascular treatment were assessed using Wilcoxon's test. RESULTS: Good inter-observer and intra-observer agreement was obtained in all patients. Good agreement was obtained for perfusion parameters for the untreated foot and in repeated studies. By comparing perfusion parameters in the treated foot, a significantly shorter mean transit time (MTT) was obtained. CONCLUSIONS: Foot CT perfusion is a feasible and reproducible technique. A significant decrease of MTT between pre- and post-revascularization suggests improved flow in the below-the-knee arteries.
Inglese
Iezzi, R., Santoro, M., Dattesi, R., La Torre, M. F., Tinelli, G., Snider, F., Bonomo, L., Foot CT perfusion in patients with peripheral arterial occlusive disease (PAOD): A feasibility study, <>, 2013; (Marzo): N/A-N/A. [doi:10.1016/j.ejrad.2012.12.021] [http://hdl.handle.net/10807/41605]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/41605
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