Recent data in mouse and rat demyelination models indicate that administration of thyroid hormone (TH) has a positive effect on the demyelination/remyelination balance. As axonal pathology has been recognized as an early neuropathological event in multiple sclerosis, and remyelination is considered a pre-eminent neuroprotective strategy, in this study we investigated whether TH administration improves nerve impulse propagation and protects axons.

Dell'Acqua, M. D., Lorenzini, L., D'Intino, G., Sivilia, S., Pasqualetti, P., Panetta, V., Paradisi, M., Filippi, M., Baiguera, C., Pizzi, M., Giardino, L., Rossini, P. M., Calzà, L., Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis, <<NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY>>, 2012; 38 (5): 454-470. [doi:10.1111/j.1365-2990.2011.01228.x] [http://hdl.handle.net/10807/41269]

Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Filippi, Mauro;Rossini, Paolo Maria;
2012

Abstract

Recent data in mouse and rat demyelination models indicate that administration of thyroid hormone (TH) has a positive effect on the demyelination/remyelination balance. As axonal pathology has been recognized as an early neuropathological event in multiple sclerosis, and remyelination is considered a pre-eminent neuroprotective strategy, in this study we investigated whether TH administration improves nerve impulse propagation and protects axons.
2012
Inglese
Dell'Acqua, M. D., Lorenzini, L., D'Intino, G., Sivilia, S., Pasqualetti, P., Panetta, V., Paradisi, M., Filippi, M., Baiguera, C., Pizzi, M., Giardino, L., Rossini, P. M., Calzà, L., Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis, <<NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY>>, 2012; 38 (5): 454-470. [doi:10.1111/j.1365-2990.2011.01228.x] [http://hdl.handle.net/10807/41269]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/41269
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