To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.

Frezza, D., Tolusso, B., Giambra, V., Gremese, E., Marchini, M., Nowik, M., Serone, E., D'addabbo, P., Mattioli, C., Canestri, S., Petricca, L., D'antona, G., Birshtein, B., Scorza, R., Ferraccioli, G., Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus, <<EARD>>, 2012; 71 (8): 1309-1315. [doi:10.1136/ard.2010.147025] [http://hdl.handle.net/10807/41196]

Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus

D; Tolusso;V; Gremese;R; Ferraccioli
2012

Abstract

To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.
Inglese
Frezza, D., Tolusso, B., Giambra, V., Gremese, E., Marchini, M., Nowik, M., Serone, E., D'addabbo, P., Mattioli, C., Canestri, S., Petricca, L., D'antona, G., Birshtein, B., Scorza, R., Ferraccioli, G., Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus, <<EARD>>, 2012; 71 (8): 1309-1315. [doi:10.1136/ard.2010.147025] [http://hdl.handle.net/10807/41196]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/41196
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