Oral cancer is the sixth most common malignancy in developed countries, representing almost 3% of malignant tumors. Tobacco use and alcohol consumption are well-established risk factors. However, the observation that most patients with oral cancer have not been exposed to these risk factors suggests that additional causes may promote oral carcinogenesis. A link has been suggested between human papillomavirus (HPV) and oral cavity cancer but the significance of HPV contribution to oral carcinogenesis as well as the prevalence of HPV infection in normal oral cavity mucosa remains debated.
Migaldi, M., Pecorari, M., Forbicini, G., Nanni, N., Grottola, A., Grandi, T., Delle Donne, G., Leocata, P., Trovato, D., Sgambato, A., Low prevalence of human papillomavirus infection in the healthy oral mucosa of a Northern Italian population, <<JOURNAL OF ORAL PATHOLOGY & MEDICINE>>, 2012; 41 (1): 16-20. [doi:10.1111/j.1600-0714.2011.01062.x] [http://hdl.handle.net/10807/40777]
Low prevalence of human papillomavirus infection in the healthy oral mucosa of a Northern Italian population
Sgambato, Alessandro
2012
Abstract
Oral cancer is the sixth most common malignancy in developed countries, representing almost 3% of malignant tumors. Tobacco use and alcohol consumption are well-established risk factors. However, the observation that most patients with oral cancer have not been exposed to these risk factors suggests that additional causes may promote oral carcinogenesis. A link has been suggested between human papillomavirus (HPV) and oral cavity cancer but the significance of HPV contribution to oral carcinogenesis as well as the prevalence of HPV infection in normal oral cavity mucosa remains debated.
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