Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic drive.
Ferrero, S., Capello, D., Svaldi, M., Boi, M., Gatti, D., Drandi, D., Rossi, D., Barbiero, S., Mantoan, B., Mantella, E., Zanni, M., Ghione, P., Larocca, A., Passera, R., Bertoni, F., Gattei, V., Forconi, F., Laurenti, L., Del Poeta, G., Marasca, R., Cortelazzo, S., Gaidano, G., Palumbo, A., Boccadoro, M., Ladetto, M., Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes, <<HAEMATOLOGICA>>, 2012; 97 (6): 849-853. [doi:10.3324/haematol.2011.052852] [http://hdl.handle.net/10807/40277]
Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes
Laurenti, Luca;
2012
Abstract
Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic drive.
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