In patients with myelodysplastic syndromes (MDS), the likelihood of having a sustained response to azacitidine is increased by maximizing treatment duration. This is important as prognosis post-relapse is poor. There is also the concern that early termination of treatment may result in rapid disease progression. We reviewed outcomes in 13 patients who discontinued azacitidine (decitabine in one patient), while still responding to the treatment. Most patients rapidly relapsed; median time to progression was 5.4 months. Reasons for treatment discontinuation included comorbidities, infections and patient choice. These findings illustrate the risk of prematurely terminating azacitidine therapy in MDS. © 2013 John Wiley & Sons A/S.

Voso, M. T., Breccia, M., Lunghi, M., Poloni, A., Niscola, P., Finelli, C., Bari, A., Musto, P., Zambello, R., Fianchi, L., Alimena, G., Leone, G., Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia, <<EUROPEAN JOURNAL OF HAEMATOLOGY>>, 2013; (Gennaio): N/A-N/A. [doi:10.1111/ejh.12079] [http://hdl.handle.net/10807/40062]

Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia

Voso, Maria Teresa;Fianchi, Luana;Leone, Giuseppe
2013

Abstract

In patients with myelodysplastic syndromes (MDS), the likelihood of having a sustained response to azacitidine is increased by maximizing treatment duration. This is important as prognosis post-relapse is poor. There is also the concern that early termination of treatment may result in rapid disease progression. We reviewed outcomes in 13 patients who discontinued azacitidine (decitabine in one patient), while still responding to the treatment. Most patients rapidly relapsed; median time to progression was 5.4 months. Reasons for treatment discontinuation included comorbidities, infections and patient choice. These findings illustrate the risk of prematurely terminating azacitidine therapy in MDS. © 2013 John Wiley & Sons A/S.
2013
Inglese
Voso, M. T., Breccia, M., Lunghi, M., Poloni, A., Niscola, P., Finelli, C., Bari, A., Musto, P., Zambello, R., Fianchi, L., Alimena, G., Leone, G., Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia, <<EUROPEAN JOURNAL OF HAEMATOLOGY>>, 2013; (Gennaio): N/A-N/A. [doi:10.1111/ejh.12079] [http://hdl.handle.net/10807/40062]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/40062
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 33
social impact