Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
Pasqualetti, P., Bonomini, C., Dal Forno, G., Paulon, L., Sinforiani, E., Marra, C., Zanetti, O., Rossini, P. M., A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease, <<AGING CLINICAL AND EXPERIMENTAL RESEARCH>>, 2009; 21 (2): 102-110. [doi:10.1007/BF03325217] [http://hdl.handle.net/10807/37929]
A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease
Marra, Camillo;Rossini, Paolo Maria
2009
Abstract
Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
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