Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

Pasqualetti, P., Bonomini, C., Dal Forno, G., Paulon, L., Sinforiani, E., Marra, C., Zanetti, O., Rossini, P. M., A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease, <<AGING CLINICAL AND EXPERIMENTAL RESEARCH>>, 2009; (21): 21-28 [http://hdl.handle.net/10807/37929]

A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Marra, Camillo;Rossini, Paolo Maria
2009

Abstract

Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
Inglese
Pasqualetti, P., Bonomini, C., Dal Forno, G., Paulon, L., Sinforiani, E., Marra, C., Zanetti, O., Rossini, P. M., A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease, <>, 2009; (21): 21-28 [http://hdl.handle.net/10807/37929]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/37929
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