Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.

Mariani, M., Shahabi, S., Sieber, S., Scambia, G., Ferlini, C., Class III β-tubulin (TUBB3): more than a biomarker in solid tumors?, <<CURRENT MOLECULAR MEDICINE>>, 2011; 11 (9): 726-731 [http://hdl.handle.net/10807/3747]

Class III β-tubulin (TUBB3): more than a biomarker in solid tumors?

Mariani, Marisa;Scambia, Giovanni;Ferlini, Cristiano
2011

Abstract

Class III β-tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.
eng
Mariani, M., Shahabi, S., Sieber, S., Scambia, G., Ferlini, C., Class III β-tubulin (TUBB3): more than a biomarker in solid tumors?, <>, 2011; 11 (9): 726-731 [http://hdl.handle.net/10807/3747]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/3747
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact