The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
Brennan, M., Delogu, G., The PE multigene family: a 'molecular mantra' for mycobacteria, <<TRENDS IN MICROBIOLOGY>>, 2002; 10 (5): 246-249 [http://hdl.handle.net/10807/3579]
The PE multigene family: a 'molecular mantra' for mycobacteria
Delogu, Giovanni
2002
Abstract
The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
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