Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

Petruccioli, E., Romagnoli, A., Corazzari, M., Coccia, E., Butera, O., Delogu, G., Piacentini, M., Girardi, E., Fimia, G., Goletti, D., Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages, <<THE JOURNAL OF INFECTIOUS DISEASES>>, 2012; 205 (9): 1425-1435. [doi:10.1093/infdis/jis226] [http://hdl.handle.net/10807/3577]

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

Delogu, Giovanni;
2012

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.
2012
Inglese
Petruccioli, E., Romagnoli, A., Corazzari, M., Coccia, E., Butera, O., Delogu, G., Piacentini, M., Girardi, E., Fimia, G., Goletti, D., Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages, <<THE JOURNAL OF INFECTIOUS DISEASES>>, 2012; 205 (9): 1425-1435. [doi:10.1093/infdis/jis226] [http://hdl.handle.net/10807/3577]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/3577
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