Introduction & Objectives: We aimed to determinate the prevalence of sexual dysfunction (SD) in a cohort of patients with Multiple Sclerosis (MS) and investigate the correlations with course of disease, disability status, lower urinary tract symptoms (LUTS) and lesion sites. Materials & Methods: One hundred and twenty-one patients, 56 males and 65 females, 22 to 79 years old (mean age 46.2; SD:12.8), with clinical syndrome of MS were consecutively and prospectively studied. Patients were divided into three clinical groups based on course of disease: primary progressive (PP), relapsing– remitting (RR) and secondary progressive (SP). We investigated SD by using IIEF for male patients and PISQ-12 for female patients. Patients were evaluated for overall disability using the Expanded Disability Status Scale (EDSS). LUTS were investigated by using international established questionnaires: ICIQ-MLUTS for male patients and ICIQ-FLUTS for female patients. Lesion sites were determined by magnetic resonance imaging (MRI). We used SPSS 13.0 for Windows for statistical analysis. Chi-square tests were used to evaluate the measure of association. Spearman’s rank correlation was used to describe the dependence between two variables. A P-value <0,05 was considered statistically significant. Results: At least one SD was reported by 42% (51 out of 121) of patients. In 40% of patients SD occurred in the early stage of disease. SDs occurred in male patients with a higher frequency compared to female patients (52% vs. 34%; p<0,05). Among male patients the most common symptom was erectile dysfunction (47%), followed by hypoactive sexual desire (26%), delayed or absent ejaculation (26%) and reduced or absent orgasms (25%). Among female patients the most common symptom was reduced or absent orgasms (37%), followed by hypoactive sexual desire (33%) and dyspareunia (31%). 52% of male patients and 44% of female patients referred an ‘unsatisfied’ sexual life. Only 48% of patients reporting SD had previously spoken to a doctor about this problem. 75 patients had RR-MS; 33 patients had SP-MS and 13 had PP-MS. We found a significant correlation between disease course and SD, that was more frequent in SP (67%) and PP (60%) patients than in RR (27%) patients (p < 0,05). A direct correlation was observed between EDSS score and SD (p < 0,05). The average EDSS score was 4,03 (SD=2,2) in patients referring SD and 2,39 (SD=1,9) in patients without SD. We observed a direct correlation also between complaint of LUTS and SD (p<0,05). No significant correlation was found between SD and lesion sites at MRI (p>0,05). Conclusions: Our data confirmed the high prevalence of SD in MS patients, even if they are often underestimated. The prevalence is higher in males than in females. We found a correlation between SD and course of disease, EDSS score and LUTS.

Sacco, E., Sebastianelli, A., Batocchi, A. P., Pinto, F., Totaro, A., Volpe, A., Racioppi, M., Gulino, G., Bassi, P., SEXUAL DYSFUNCTIONS IN PATIENTS AFFECTED BY MULTIPLE SCLEROSIS: EVALUATION IN A CONTEMPORARY COHORT FROM A REFERRAL CENTER, Comunicazione, in EUROPEAN UROLOGY SUPPLEMENTS, (Vienna, 18-22 March 2011), ELSEVIER SCIENCE BV, Amsterdam 2011: 160-160 [http://hdl.handle.net/10807/3573]

SEXUAL DYSFUNCTIONS IN PATIENTS AFFECTED BY MULTIPLE SCLEROSIS: EVALUATION IN A CONTEMPORARY COHORT FROM A REFERRAL CENTER

Sacco, Emilio;Batocchi, Anna Paola;Pinto, Francesco;Totaro, Angelo;Racioppi, Marco;Gulino, Gaetano;Bassi, Pierfrancesco
2011

Abstract

Introduction & Objectives: We aimed to determinate the prevalence of sexual dysfunction (SD) in a cohort of patients with Multiple Sclerosis (MS) and investigate the correlations with course of disease, disability status, lower urinary tract symptoms (LUTS) and lesion sites. Materials & Methods: One hundred and twenty-one patients, 56 males and 65 females, 22 to 79 years old (mean age 46.2; SD:12.8), with clinical syndrome of MS were consecutively and prospectively studied. Patients were divided into three clinical groups based on course of disease: primary progressive (PP), relapsing– remitting (RR) and secondary progressive (SP). We investigated SD by using IIEF for male patients and PISQ-12 for female patients. Patients were evaluated for overall disability using the Expanded Disability Status Scale (EDSS). LUTS were investigated by using international established questionnaires: ICIQ-MLUTS for male patients and ICIQ-FLUTS for female patients. Lesion sites were determined by magnetic resonance imaging (MRI). We used SPSS 13.0 for Windows for statistical analysis. Chi-square tests were used to evaluate the measure of association. Spearman’s rank correlation was used to describe the dependence between two variables. A P-value <0,05 was considered statistically significant. Results: At least one SD was reported by 42% (51 out of 121) of patients. In 40% of patients SD occurred in the early stage of disease. SDs occurred in male patients with a higher frequency compared to female patients (52% vs. 34%; p<0,05). Among male patients the most common symptom was erectile dysfunction (47%), followed by hypoactive sexual desire (26%), delayed or absent ejaculation (26%) and reduced or absent orgasms (25%). Among female patients the most common symptom was reduced or absent orgasms (37%), followed by hypoactive sexual desire (33%) and dyspareunia (31%). 52% of male patients and 44% of female patients referred an ‘unsatisfied’ sexual life. Only 48% of patients reporting SD had previously spoken to a doctor about this problem. 75 patients had RR-MS; 33 patients had SP-MS and 13 had PP-MS. We found a significant correlation between disease course and SD, that was more frequent in SP (67%) and PP (60%) patients than in RR (27%) patients (p < 0,05). A direct correlation was observed between EDSS score and SD (p < 0,05). The average EDSS score was 4,03 (SD=2,2) in patients referring SD and 2,39 (SD=1,9) in patients without SD. We observed a direct correlation also between complaint of LUTS and SD (p<0,05). No significant correlation was found between SD and lesion sites at MRI (p>0,05). Conclusions: Our data confirmed the high prevalence of SD in MS patients, even if they are often underestimated. The prevalence is higher in males than in females. We found a correlation between SD and course of disease, EDSS score and LUTS.
2011
Inglese
EUROPEAN UROLOGY SUPPLEMENTS
26th annual EAU congress 2011
Vienna
Comunicazione
18-mar-2011
22-mar-2011
Sacco, E., Sebastianelli, A., Batocchi, A. P., Pinto, F., Totaro, A., Volpe, A., Racioppi, M., Gulino, G., Bassi, P., SEXUAL DYSFUNCTIONS IN PATIENTS AFFECTED BY MULTIPLE SCLEROSIS: EVALUATION IN A CONTEMPORARY COHORT FROM A REFERRAL CENTER, Comunicazione, in EUROPEAN UROLOGY SUPPLEMENTS, (Vienna, 18-22 March 2011), ELSEVIER SCIENCE BV, Amsterdam 2011: 160-160 [http://hdl.handle.net/10807/3573]
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