BACKGROUND: Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training. METHODS: We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training. RESULTS: No differences (P>0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to T0 (P<0.01). In PSM, S100B was higher than controls (P<0.001) at T0 and T1. S100B% at T0-T1 was higher (P<0.001) in PSM and in controls and between PSM and controls (P<0.001). CONCLUSIONS: Increased saliva S100B levels in PSM before and after training suggest a paracrine/autocrine protein's role connected to stressing activity, which becomes especially evident in PSMs.

Michetti, F., Bruschettini, M., Frigiola, A., Abella, R., Giamberti, A., Marchese, N., Mangraviti, S., Melioli, G., Baldari, A., Bruschettini, P., Gazzolo, D., Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity, <<CLINICAL BIOCHEMISTRY>>, 2011; 2011 (44): 245-247 [http://hdl.handle.net/10807/3547]

Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity

Michetti, Fabrizio;
2011

Abstract

BACKGROUND: Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training. METHODS: We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training. RESULTS: No differences (P>0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to T0 (P<0.01). In PSM, S100B was higher than controls (P<0.001) at T0 and T1. S100B% at T0-T1 was higher (P<0.001) in PSM and in controls and between PSM and controls (P<0.001). CONCLUSIONS: Increased saliva S100B levels in PSM before and after training suggest a paracrine/autocrine protein's role connected to stressing activity, which becomes especially evident in PSMs.
Inglese
Michetti, F., Bruschettini, M., Frigiola, A., Abella, R., Giamberti, A., Marchese, N., Mangraviti, S., Melioli, G., Baldari, A., Bruschettini, P., Gazzolo, D., Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity, <<CLINICAL BIOCHEMISTRY>>, 2011; 2011 (44): 245-247 [http://hdl.handle.net/10807/3547]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/3547
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