BACKGROUND: 4-L polyethylene glycol preparations are effective for colon cleansing before colonoscopy. However, large volume and unpleasant taste reduce tolerability and acceptability limiting patient compliance. A new isosmotic low-volume polyethylene glycol preparation with citrates and simethicone plus bisacodyl has been developed to improve patient compliance and tolerability. AIM: To compare the efficacy of 2 different regimens of preparation vs a split-dose of polyethylene glycol solution. PATIENTS AND METHODS: In this randomised, blinded, comparative study, 153 patients were allocated to 3 arms. Arm 1 (n=52) received bisacodyl and 2-L polyethylene glycol with citrates and simethicone the day before the procedure. Arm 2 (n=50) received bisacodyl the day before and 2-L polyethylene glycol with citrates and simethicone on the day of colonoscopy. Control group (n=51) received a split-dose of 4-L polyethylene glycol. Cleansing was evaluated according to Ottawa scale. RESULTS: The mean Ottawa score was not different in the 3 groups. Excellent cleansing was observed more frequently in arm 2 (70%) than in controls (49%) (p<0.05). No serious adverse events were observed in the 3 regimens. The willingness to repeat the same bowel preparation was superior in arms 1 and 2 than in controls (p<0.001). CONCLUSIONS: New low-volume preparations seem to be as effective as the split 4-L polyethylene glycol regimen, showing a better tolerability and acceptability.

Cesaro, P., Hassan, C., Spada, C., Petruzziello, L., Vitale, G., Costamagna, G., A new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4L polyethylene glycol for bowel cleansing prior to colonoscopy: A randomised controlled trial, <<DIGESTIVE AND LIVER DISEASE>>, N/A; (Agosto): N/A-N/A. [doi:10.1016/j.dld.2012.07.011] [http://hdl.handle.net/10807/35145]

A new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4L polyethylene glycol for bowel cleansing prior to colonoscopy: A randomised controlled trial

Cesaro, Paola;Hassan, Cesare;Spada, Cristiano;Petruzziello, Lucio;Vitale, Giovanna;Costamagna, Guido
2012

Abstract

BACKGROUND: 4-L polyethylene glycol preparations are effective for colon cleansing before colonoscopy. However, large volume and unpleasant taste reduce tolerability and acceptability limiting patient compliance. A new isosmotic low-volume polyethylene glycol preparation with citrates and simethicone plus bisacodyl has been developed to improve patient compliance and tolerability. AIM: To compare the efficacy of 2 different regimens of preparation vs a split-dose of polyethylene glycol solution. PATIENTS AND METHODS: In this randomised, blinded, comparative study, 153 patients were allocated to 3 arms. Arm 1 (n=52) received bisacodyl and 2-L polyethylene glycol with citrates and simethicone the day before the procedure. Arm 2 (n=50) received bisacodyl the day before and 2-L polyethylene glycol with citrates and simethicone on the day of colonoscopy. Control group (n=51) received a split-dose of 4-L polyethylene glycol. Cleansing was evaluated according to Ottawa scale. RESULTS: The mean Ottawa score was not different in the 3 groups. Excellent cleansing was observed more frequently in arm 2 (70%) than in controls (49%) (p<0.05). No serious adverse events were observed in the 3 regimens. The willingness to repeat the same bowel preparation was superior in arms 1 and 2 than in controls (p<0.001). CONCLUSIONS: New low-volume preparations seem to be as effective as the split 4-L polyethylene glycol regimen, showing a better tolerability and acceptability.
Inglese
Cesaro, P., Hassan, C., Spada, C., Petruzziello, L., Vitale, G., Costamagna, G., A new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4L polyethylene glycol for bowel cleansing prior to colonoscopy: A randomised controlled trial, <<DIGESTIVE AND LIVER DISEASE>>, N/A; (Agosto): N/A-N/A. [doi:10.1016/j.dld.2012.07.011] [http://hdl.handle.net/10807/35145]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/35145
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