Take Home Message We describe the rationale for using quantification of Gleason pattern 4 rather than the proportion of Gleason patterns for risk stratification in prostate cancer, as proposed by the ProQuant Group. We outline research that will be conducted to assess this strategy, and invite individuals interested in collaboration to join the group.

Vickers, A. J., Fine, S., Oddens, J., Jager, A., Postema, A. W., Beerlage, H., Lamb, A. D., Schlomm, T., Horst, D., Elversang, J., Germer, U., Nielsen, T. K., Stroomberg, H. V., Røder, A., Trivedi, H., Gichoya, J. W., Patil, D., Sanda, M., Rocco, B. M. C., Sighinolfi, M. C., Zannoni, G. F., Elversang, J., Lischalk, J., Germer, U., Nielsen, T. K., Kowalczyk, K., Saiz, M., Compérat, E., Wasinger, G., Rivas, J. G., Nordström, T., Kartasalo, K., Eklund, M., Egevad, L., Sandeman, K., Bjartell, A., Carlsson, S., Horst, D., Graefen, M., Assel, M., Nagar, H., Ehdaie, B., Ong, W. L., Pham, A., Tay, H. S., Ryan, A., Grummet, J., Gesztes, W., Litjens, G., Lischalk, J., Roberts, M., Briganti, A., Scuderi, S., Gandaglia, G., Freeman, A., Haider, A., Kasivisvanathan, V., Rajwa, P., Ng, A. B. C. D., Menon, A. A., Fleshner, N., Zabihollahy, F., Poyet, C., Gevaert, T., Meerleer, G. D., Joniau, S., Giesen, A., Everaerts, W., Luetkens, J., Krausewitz, P., Bernhardt, M., Kristiansen, G., Sisk, A., Raman, S., Kwan, L., Weiner, A., Reiter, R. E., Eggener, S., Marks, L., Brisbane, W., Simko, J., Ding, C., Cooperberg, M., Carroll, P., Cowan, J., Paner, G., Liauw, S., Skolarus, T., Sidana, A., Shen, X., Chen, R., Leroy, X., Sisk, A., Raman, S., Arnold, C., Kwan, L., Olivier, J., Villers, A., Marks, L., Mehra, R., Morgan, T., Bryant, R., Verrill, C., Taimen, P., Boström, P., Ettala, O., Högerman, M., Oszwald, A., Compérat, E., Wasinger, G., Shariat, S., Bianco, F. J., Gordetsky, J. B., Postema, A. W., Tosoian, J., Barocas, D. A., Humphrey, P., Onofrey, J., Kim, I., Leapman, M., Sparkle, P., Evaluating Tumor Quantification in Place of Proportions in Prostate Cancer: Principles of the ProQuant Group, <<EUROPEAN UROLOGY>>, 2026; 89 (4): 298-301. [doi:10.1016/j.eururo.2025.11.013] [https://hdl.handle.net/10807/347700]

Evaluating Tumor Quantification in Place of Proportions in Prostate Cancer: Principles of the ProQuant Group

Rocco, Bernardo Maria Cesare;Sighinolfi, Maria Chiara;Zannoni, Gian Franco;
2026

Abstract

Take Home Message We describe the rationale for using quantification of Gleason pattern 4 rather than the proportion of Gleason patterns for risk stratification in prostate cancer, as proposed by the ProQuant Group. We outline research that will be conducted to assess this strategy, and invite individuals interested in collaboration to join the group.
2026
Inglese
Vickers, A. J., Fine, S., Oddens, J., Jager, A., Postema, A. W., Beerlage, H., Lamb, A. D., Schlomm, T., Horst, D., Elversang, J., Germer, U., Nielsen, T. K., Stroomberg, H. V., Røder, A., Trivedi, H., Gichoya, J. W., Patil, D., Sanda, M., Rocco, B. M. C., Sighinolfi, M. C., Zannoni, G. F., Elversang, J., Lischalk, J., Germer, U., Nielsen, T. K., Kowalczyk, K., Saiz, M., Compérat, E., Wasinger, G., Rivas, J. G., Nordström, T., Kartasalo, K., Eklund, M., Egevad, L., Sandeman, K., Bjartell, A., Carlsson, S., Horst, D., Graefen, M., Assel, M., Nagar, H., Ehdaie, B., Ong, W. L., Pham, A., Tay, H. S., Ryan, A., Grummet, J., Gesztes, W., Litjens, G., Lischalk, J., Roberts, M., Briganti, A., Scuderi, S., Gandaglia, G., Freeman, A., Haider, A., Kasivisvanathan, V., Rajwa, P., Ng, A. B. C. D., Menon, A. A., Fleshner, N., Zabihollahy, F., Poyet, C., Gevaert, T., Meerleer, G. D., Joniau, S., Giesen, A., Everaerts, W., Luetkens, J., Krausewitz, P., Bernhardt, M., Kristiansen, G., Sisk, A., Raman, S., Kwan, L., Weiner, A., Reiter, R. E., Eggener, S., Marks, L., Brisbane, W., Simko, J., Ding, C., Cooperberg, M., Carroll, P., Cowan, J., Paner, G., Liauw, S., Skolarus, T., Sidana, A., Shen, X., Chen, R., Leroy, X., Sisk, A., Raman, S., Arnold, C., Kwan, L., Olivier, J., Villers, A., Marks, L., Mehra, R., Morgan, T., Bryant, R., Verrill, C., Taimen, P., Boström, P., Ettala, O., Högerman, M., Oszwald, A., Compérat, E., Wasinger, G., Shariat, S., Bianco, F. J., Gordetsky, J. B., Postema, A. W., Tosoian, J., Barocas, D. A., Humphrey, P., Onofrey, J., Kim, I., Leapman, M., Sparkle, P., Evaluating Tumor Quantification in Place of Proportions in Prostate Cancer: Principles of the ProQuant Group, <<EUROPEAN UROLOGY>>, 2026; 89 (4): 298-301. [doi:10.1016/j.eururo.2025.11.013] [https://hdl.handle.net/10807/347700]
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