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EnglishAll iodinated contrast media (CM) are known to cause both immediate (</=1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future.
Romano, A., Management of hypersensitivity reactions to iodinated contrast media., <<ALLERGY>>, 2005; (60): 150-158 [http://hdl.handle.net/10807/34282]
| Autori: | |
| Titolo: | Management of hypersensitivity reactions to iodinated contrast media. |
| Data di pubblicazione: | 2005 |
| Abstract: | All iodinated contrast media (CM) are known to cause both immediate (</=1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Romano, A., Management of hypersensitivity reactions to iodinated contrast media., <<ALLERGY>>, 2005; (60): 150-158 [http://hdl.handle.net/10807/34282] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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