Malignant cells can exploit numerous mechanisms to evade anti-tumor immunity. In this issue of Cancer Cell, Foidart et al. demonstrate that neoplastic cells undergoing whole-genome doubling acquire epigenetic changes that actively suppress antigen presentation, hence effectively hiding from recognition and elimination by CD8+ T lymphocytes.
Galluzzi, L., Manic, G., Vitale, I., An epigenetic four-lane route to camouflage for cancer cells, <<CANCER CELL>>, 2026; (N/A): N/A-N/A. [doi:10.1016/j.ccell.2026.05.017] [https://hdl.handle.net/10807/341575]
An epigenetic four-lane route to camouflage for cancer cells
Vitale, Ilio
Ultimo
2026
Abstract
Malignant cells can exploit numerous mechanisms to evade anti-tumor immunity. In this issue of Cancer Cell, Foidart et al. demonstrate that neoplastic cells undergoing whole-genome doubling acquire epigenetic changes that actively suppress antigen presentation, hence effectively hiding from recognition and elimination by CD8+ T lymphocytes.
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