A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N-iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not observed. The procedure represents a metal free spirocyclization of indoles with an opportunity for further functionalizations.
Fedoseev, P., Coppola, G., Ojeda, G. M., Van Der Eycken, E. V., Synthesis of spiroindolenines by intramolecular: Ipso -iodocyclization of indol ynones, <<CHEMICAL COMMUNICATIONS>>, 2018; 54 (29): 3625-3628. [doi:10.1039/c8cc01474d] [https://hdl.handle.net/10807/341558]
Synthesis of spiroindolenines by intramolecular: Ipso -iodocyclization of indol ynones
Coppola, Guglielmo;
2018
Abstract
A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N-iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not observed. The procedure represents a metal free spirocyclization of indoles with an opportunity for further functionalizations.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
