The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.
Totaro, M., Tolusso, B., Napolioni, V., Faustini, F., Canestri, S., Mannocci, A., Gremese, E., Bosello, S., Alivernini, S., Ferraccioli, G., PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis, <<PLOS ONE>>, 2011; 6 (9): e24292-e24292. [doi:10.1371/journal.pone.0024292] [http://hdl.handle.net/10807/3409]
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis
Tolusso, Barbara;Faustini, Francesca;Mannocci, Alice;Gremese, Elisa;Alivernini, Stefano;Ferraccioli, Gianfranco
2011
Abstract
The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.
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