Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.
Barone, L., Colicchio, G., Policicchio, D., Di Clemente, F., Di Monaco, A., Meglio, M., Lanza, G. A., Crea, F., Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy, <<NEUROIMMUNOMODULATION>>, 2007; 14 (6): 331-336. [doi:10.1159/000127360] [http://hdl.handle.net/10807/34000]
Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy
Barone, Lucy;Colicchio, Gabriella;Policicchio, Domenico;Di Clemente, Francesca;Di Monaco, Antonio;Meglio, Mario;Lanza, Gaetano Antonio;Crea, Filippo
2007
Abstract
Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.
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