At least four premature newborn complications have been reported to be associated with low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis and brain damage. Local IGF-I concentrations have only been reported for bronchopulmonary dysplasia and these findings show that lung IGF-I levels are clearly increased (epithelial lining fluid levels), emphasizing the fact that IGF-I is differently regulated in the general circulation or at local level. The present review discusses the meaning of the association between serum IGF-I amounts and development of complications in premature newborns. Finally, some methodological indications are reported regarding the IGF-I assay procedures. It is important to establish what are the possible relationships between blood levels and those of different compartments involved in the diseases.

Capoluongo, E. D., Ameglio, F., Zuppi, C., Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia., <<CLINICAL CHEMISTRY AND LABORATORY MEDICINE>>, 2008; (Agosto): 1061-1066 [http://hdl.handle.net/10807/33872]

Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia.

Capoluongo, Ettore Domenico;Zuppi, Cecilia
2008

Abstract

At least four premature newborn complications have been reported to be associated with low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis and brain damage. Local IGF-I concentrations have only been reported for bronchopulmonary dysplasia and these findings show that lung IGF-I levels are clearly increased (epithelial lining fluid levels), emphasizing the fact that IGF-I is differently regulated in the general circulation or at local level. The present review discusses the meaning of the association between serum IGF-I amounts and development of complications in premature newborns. Finally, some methodological indications are reported regarding the IGF-I assay procedures. It is important to establish what are the possible relationships between blood levels and those of different compartments involved in the diseases.
Inglese
Capoluongo, E. D., Ameglio, F., Zuppi, C., Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia., <<CLINICAL CHEMISTRY AND LABORATORY MEDICINE>>, 2008; (Agosto): 1061-1066 [http://hdl.handle.net/10807/33872]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/33872
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