The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side effects of immune-based medical intervention. Features reported in our review will allow both clinicians and basic science researchers to take home ideas to improve their knowledge about SARS-CoV-2.
Quirino, A., Marascio, N., Barreca, G. S., Gallo, L., Giancotti, A., Lamberti, A. G., Peronace, C., Trecarichi, E. M., Fusco, P., Mazzitelli, M., Divenuto, F., Pavia, G., Suraci, A., Matera, G., Liberto, M. C., Sars-cov-2: Some aspects of molecular evolution, cellular pathogenesis, and immune system mechanism elusion, <<APPLIED SCIENCES>>, 2021; 11 (24): N/A-N/A. [doi:10.3390/app112411605] [https://hdl.handle.net/10807/338483]
Sars-cov-2: Some aspects of molecular evolution, cellular pathogenesis, and immune system mechanism elusion
Trecarichi, Enrico Maria;Mazzitelli, Maria;
2021
Abstract
The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side effects of immune-based medical intervention. Features reported in our review will allow both clinicians and basic science researchers to take home ideas to improve their knowledge about SARS-CoV-2.
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