PFAPA syndrome is a topic of huge discussion and future directions of research should attempt to fix the gap of knowledge related to disease persistence, evolution, or resolution, highlighting the inflammatory architecture of lymphoid tissue of tonsils (including the microbiome), and the manner by which variants in genes causing autoinflammatory syndromes modulate the PFAPA phenotype.
Rigante, D., Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome: a conundrum still hard to solve., <<PEDIATRIC RESEARCH>>, 2026; 2026 (June): 1-2. [doi:10.1038/s41390-026-05188-w] [https://hdl.handle.net/10807/337816]
Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome: a conundrum still hard to solve.
Rigante, Donato
2026
Abstract
PFAPA syndrome is a topic of huge discussion and future directions of research should attempt to fix the gap of knowledge related to disease persistence, evolution, or resolution, highlighting the inflammatory architecture of lymphoid tissue of tonsils (including the microbiome), and the manner by which variants in genes causing autoinflammatory syndromes modulate the PFAPA phenotype.
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