In this study, we retrospectively analyzed clinical and demographic data from 842 consecutive breast cancer patients who underwent conservative mastectomy with prepectoral implant-based breast reconstruction (IBBR) from January 2018 to December 2023 at Fondazione Policlinico Universitario Agostino Gemelli IRCCS in Rome. Several retrospective studies and meta-analyses have demonstrated that prepectoral IBBR is a safe surgical option, yielding clinical outcomes comparable to the subpectoral approach. However, there is limited evidence regarding residual breast tissue after conservative mastectomy, which remains a potential risk for local recurrence. The oncological safety of conservative mastectomy, when combined with prepectoral IBBR, remains a topic of ongoing discussion. This is the first study in the literature with such a large sample size comparing the oncological outcomes of conservative mastectomy combined with prepectoral IBBR to the subpectoral technique.
Scardina, L., Di Leone, A., Sanchez, A. M., Accetta, C., Barone Adesi, L., Biondi, E., Carnassale, B., D'Archi, S., De Lauretis, F., Di Guglielmo, E., De Franco, A., Magno, S., Moschella, F., Natale, M., Salgarello, M., Savia, E., Silenzi, M., Visconti, G., Masetti, R., Franceschini, G., Oncological Safety of Prepectoral Implant-Based Breast Reconstruction After Conservative Mastectomy: Insights from 842 Consecutive Breast Cancer Patients, <<CANCERS>>, 2025; 17 (6): 1-6. [doi:10.3390/cancers17060925] [https://hdl.handle.net/10807/337341]
Oncological Safety of Prepectoral Implant-Based Breast Reconstruction After Conservative Mastectomy: Insights from 842 Consecutive Breast Cancer Patients
Scardina, Lorenzo;Di Leone, Alba;Sanchez, Alejandro Martin;Accetta, Cristina;Barone Adesi, Liliana;D'Archi, Sabatino;Di Guglielmo, Enrico;De Franco, Antonio;Magno, Stefano;Moschella, Francesca;Salgarello, Marzia;Visconti, Giuseppe;Masetti, Riccardo;Franceschini, Gianluca
2025
Abstract
In this study, we retrospectively analyzed clinical and demographic data from 842 consecutive breast cancer patients who underwent conservative mastectomy with prepectoral implant-based breast reconstruction (IBBR) from January 2018 to December 2023 at Fondazione Policlinico Universitario Agostino Gemelli IRCCS in Rome. Several retrospective studies and meta-analyses have demonstrated that prepectoral IBBR is a safe surgical option, yielding clinical outcomes comparable to the subpectoral approach. However, there is limited evidence regarding residual breast tissue after conservative mastectomy, which remains a potential risk for local recurrence. The oncological safety of conservative mastectomy, when combined with prepectoral IBBR, remains a topic of ongoing discussion. This is the first study in the literature with such a large sample size comparing the oncological outcomes of conservative mastectomy combined with prepectoral IBBR to the subpectoral technique.
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