In colorectal small‐cell neuroendocrine carcinoma, superficial endoscopic biopsies may be misleading due to predominant submucosal growth. When endoscopic features strongly suggest malignancy despite benign histology, deep biopsies and early multidisciplinary evaluation are essential.
Verbo, A., Endoscopic histologic discordance in colorectal small-cell neuroendocrine carcinoma: the need for deep biopsies, <<CLINICAL CASE REPORTS: OPEN ACCESS>>, 2026; (1): 1-5 [https://hdl.handle.net/10807/336315]
Endoscopic histologic discordance in colorectal small-cell neuroendocrine carcinoma: the need for deep biopsies
Verbo, Alessandro
Primo
Membro del Collaboration Group
2026
Abstract
In colorectal small‐cell neuroendocrine carcinoma, superficial endoscopic biopsies may be misleading due to predominant submucosal growth. When endoscopic features strongly suggest malignancy despite benign histology, deep biopsies and early multidisciplinary evaluation are essential.
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