There is an increasing interest in studying the role of GABAergic medications in the treatment of alcohol dependence. The GABAergic drug gamma-hydroxybutyric acid (GHB) has been investigated in Europe as a possible treatment for alcohol dependence. In some European Countries, GHB has been approved as a treatment for alcohol dependence. However, this drug has also shown addictive properties, therefore raising questions about its safety in treating alcohol-dependent subjects. More recent research is focusing on the possibility of identifying alcohol-dependent subtypes without risk of developing GHB abuse. Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations.

Addolorato, G., Leggio, L., Ferrulli, A., Caputo, F., Gasbarrini, G. B., The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data, <<EXPERT OPINION ON INVESTIGATIONAL DRUGS>>, 2009; 18 (Maggio): 675-686 [http://hdl.handle.net/10807/33227]

The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data

Addolorato, Giovanni;Leggio, Lorenzo;Ferrulli, Anna;Gasbarrini, Giovanni Battista
2009

Abstract

There is an increasing interest in studying the role of GABAergic medications in the treatment of alcohol dependence. The GABAergic drug gamma-hydroxybutyric acid (GHB) has been investigated in Europe as a possible treatment for alcohol dependence. In some European Countries, GHB has been approved as a treatment for alcohol dependence. However, this drug has also shown addictive properties, therefore raising questions about its safety in treating alcohol-dependent subjects. More recent research is focusing on the possibility of identifying alcohol-dependent subtypes without risk of developing GHB abuse. Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations.
2009
Inglese
Addolorato, G., Leggio, L., Ferrulli, A., Caputo, F., Gasbarrini, G. B., The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data, <<EXPERT OPINION ON INVESTIGATIONAL DRUGS>>, 2009; 18 (Maggio): 675-686 [http://hdl.handle.net/10807/33227]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/33227
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