Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in < 10 min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2 mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.
Pavone, M., Rebiere, L., Lecointre, L., Carles, E., Tondon, C., Van Quyen, P. L., Seeliger, B., Giannarelli, D., Lampert, T., Bizzarri, N., Scambia, G., Akladios, C., Nicolae, A., Querleu, D., Venkatasamy, A., Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography, <<SCIENTIFIC REPORTS>>, 2025; 15 (1): N/A-N/A. [doi:10.1038/s41598-025-16570-9] [https://hdl.handle.net/10807/325034]
Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography
Pavone, Matteo
Primo
;Giannarelli, Diana;Scambia, Giovanni;
2025
Abstract
Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in < 10 min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2 mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.
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