We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hypertriglyceridemia persisted, and the patient died of multiorgan failure. HPS is a rare, but life-threatening complication of EBV infection.
Torti, L., Larocca, L. M., Massini, G., Cuccaro, A., Maiolo, E., Santangelo, R., Bianchi, M., Pennisi, M. A., Hohaus, S., Teofili, L., Epstein-Barr Virus (EBV)-Associated Haemophagocytic Syndrome, <<MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES>>, 2012; 4 (1): N/A-N/A. [doi:10.4084/MJHID.2012.008] [https://hdl.handle.net/10807/317042]
Epstein-Barr Virus (EBV)-Associated Haemophagocytic Syndrome
Larocca, Luigi Maria;Cuccaro, Annarosa;Maiolo, Elena;Santangelo, Rosaria;Pennisi, Mariano Alberto;Hohaus, Stefan;Teofili, Luciana
2012
Abstract
We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hypertriglyceridemia persisted, and the patient died of multiorgan failure. HPS is a rare, but life-threatening complication of EBV infection.
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