Mesenchymal stem cells (MSCs) are multipotent cells, able to differentiate into elements of the mesodermal lineage. Bone marrow and adipose tissue represent the main sources for MSC isolation. In the last decade, several studies have reported the plasticity of MSCs toward a hepatocyte-like phenotype. The use of MSCs to generate hepatocyte-like cells holds great promises to overcome the scarcity of available organs for transplantation. However, little is known about the molecular pathways involved in lineage cross-differentiation and several issues remain to be answered before MSC application in clinical settings. Aim of this review is to critically analyze the possible sources of MSCs suitable for liver repopulation and the molecular mechanisms underlying MSC hepatic differentiation.

Puglisi, M. A., Saulnier, N., Piscaglia, A., Tondi, P., Agnes, S., Gasbarrini, A., Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2011; 15 (4): 355-364 [http://hdl.handle.net/10807/3163]

Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives

Puglisi;Maria Ausiliatrice; Saulnier;Ac; Tondi;Paolo; Agnes;Salvatore; Gasbarrini
2011

Abstract

Mesenchymal stem cells (MSCs) are multipotent cells, able to differentiate into elements of the mesodermal lineage. Bone marrow and adipose tissue represent the main sources for MSC isolation. In the last decade, several studies have reported the plasticity of MSCs toward a hepatocyte-like phenotype. The use of MSCs to generate hepatocyte-like cells holds great promises to overcome the scarcity of available organs for transplantation. However, little is known about the molecular pathways involved in lineage cross-differentiation and several issues remain to be answered before MSC application in clinical settings. Aim of this review is to critically analyze the possible sources of MSCs suitable for liver repopulation and the molecular mechanisms underlying MSC hepatic differentiation.
Inglese
Puglisi, M. A., Saulnier, N., Piscaglia, A., Tondi, P., Agnes, S., Gasbarrini, A., Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2011; 15 (4): 355-364 [http://hdl.handle.net/10807/3163]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/3163
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