Background/Objectives: Alexithymia, emotion regulation, and impulsivity are key factors in youths with mood disorders. However, gender differences within these dimensions remain insufficiently studied in this population. This study seeks to explore these dimensions in a sample of adolescents and young adults with mood disorders, aiming to identify gender-specific characteristics with important clinical implications. Methods: We assessed 115 outpatients aged 13 to 25 years with a DSM-5 diagnosis of mood disorder. The evaluation included the Toronto Alexithymia Scale (TAS-20), the Difficulties in Emotion Regulation Scale (DERS), and the UPPS-P Impulsive Behavior Scale. The associations with suicidal ideation were tested using two different multivariate models. Results were controlled for age and intelligence measures. Results: The first model (Wilks’ Lambda = 0.720, p < 0.001) revealed significantly higher scores in women than men for TAS-20 (p < 0.001), DERS (p < 0.001), and the UPPS-P subscales “Lack of Premeditation” (p = 0.004) and “Lack of Perseverance” (p = 0.001). Regression analyses confirmed gender as a significant predictor of these variables, also controlling for age and intelligence. Furthermore, intelligence measure influenced Lack of Premeditation and age influenced Lack of Perseverance. Conclusions: Women with mood disorders exhibit greater alexithymia, emotional dysregulation, and impulsivity, particularly in difficulties with planning and task persistence. These findings highlight the need for gender-sensitive interventions that address emotional awareness and impulse control to improve clinical outcomes.

Di Benedetto, L., Pinto, M., Ieritano, V., Lisci, F. M., Monti, L., Marconi, E., Chieffo, D. P. R., Montanari, S., Kotzalidis, G. D., Sani, G., Janiri, D., Gender Differences in Alexithymia, Emotion Regulation, and Impulsivity in Young Individuals with Mood Disorders, <<JOURNAL OF CLINICAL MEDICINE>>, 2025; 14 (6): N/A-N/A. [doi:10.3390/jcm14062030] [https://hdl.handle.net/10807/313632]

Gender Differences in Alexithymia, Emotion Regulation, and Impulsivity in Young Individuals with Mood Disorders

Di Benedetto, Luca;Ieritano, Valentina;Lisci, Francesco Maria;Monti, Laura;Marconi, Elisa;Chieffo, Daniela Pia Rosaria;Montanari, Silvia;Sani, Gabriele;Janiri, Delfina
2025

Abstract

Background/Objectives: Alexithymia, emotion regulation, and impulsivity are key factors in youths with mood disorders. However, gender differences within these dimensions remain insufficiently studied in this population. This study seeks to explore these dimensions in a sample of adolescents and young adults with mood disorders, aiming to identify gender-specific characteristics with important clinical implications. Methods: We assessed 115 outpatients aged 13 to 25 years with a DSM-5 diagnosis of mood disorder. The evaluation included the Toronto Alexithymia Scale (TAS-20), the Difficulties in Emotion Regulation Scale (DERS), and the UPPS-P Impulsive Behavior Scale. The associations with suicidal ideation were tested using two different multivariate models. Results were controlled for age and intelligence measures. Results: The first model (Wilks’ Lambda = 0.720, p < 0.001) revealed significantly higher scores in women than men for TAS-20 (p < 0.001), DERS (p < 0.001), and the UPPS-P subscales “Lack of Premeditation” (p = 0.004) and “Lack of Perseverance” (p = 0.001). Regression analyses confirmed gender as a significant predictor of these variables, also controlling for age and intelligence. Furthermore, intelligence measure influenced Lack of Premeditation and age influenced Lack of Perseverance. Conclusions: Women with mood disorders exhibit greater alexithymia, emotional dysregulation, and impulsivity, particularly in difficulties with planning and task persistence. These findings highlight the need for gender-sensitive interventions that address emotional awareness and impulse control to improve clinical outcomes.
2025
AREA06 - SCIENZE MEDICHE
Pubblicazione su rivista con Impact Factor
Inglese
Articolo in rivista
Inglese
adolescents
alexithymia
early intervention
emotion regulation
gender differences
impulsivity
mood disorders
psychiatric disorders
youth psychopathology
Settore MEDS-11/A - Psichiatria
Multidisciplinary Digital Publishing Institute (MDPI)
14
6
2025
N/A
N/A
2030
Goal 3: Good health and well-being
info:eu-repo/semantics/article
Di Benedetto, L., Pinto, M., Ieritano, V., Lisci, F. M., Monti, L., Marconi, E., Chieffo, D. P. R., Montanari, S., Kotzalidis, G. D., Sani, G., Janiri, D., Gender Differences in Alexithymia, Emotion Regulation, and Impulsivity in Young Individuals with Mood Disorders, <<JOURNAL OF CLINICAL MEDICINE>>, 2025; 14 (6): N/A-N/A. [doi:10.3390/jcm14062030] [https://hdl.handle.net/10807/313632]
open
262
Di Benedetto, Luca; Pinto, Mario; Ieritano, Valentina; Lisci, Francesco Maria; Monti, Laura; Marconi, Elisa; Chieffo, Daniela Pia Rosaria; Montanari, ...espandi
11
art_per_29
03. Contributo in rivista::Articolo in rivista, Nota a sentenza
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