Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.
Vecchio, A., Colasuonno, F., Occhigrossi, L., Pitolli, C., Bellanca, V., Ciccarone, F., D'Eletto, M., Di Sano, F., Pagliarini, V., Sette, C., Piacentini, M., Rossin, F., Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis, <<CELLULAR AND MOLECULAR LIFE SCIENCES>>, 2025; 82 (1): 154-169. [doi:10.1007/s00018-025-05640-w] [https://hdl.handle.net/10807/313377]
Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Pitolli, Consuelo;Pagliarini, Vittoria;Sette, Claudio;
2025
Abstract
Transglutaminase 2 protein (TG2) is necessary to induce necroptosis. Cells lacking TG2 show a strong downregulation of Ripk3 gene. TG2 allows Ripk3 gene expression by promoting the serotonylation on H3K4me3 histone.
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