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EnglishLeukotriene (LT) B(4) is a potent inflammatory lipid mediator that has been involved in the pathophysiology of respiratory diseases including asthma. Exhaled breath condensate (EBC) is a non-invasive method to sample secretions from the airways. LC/MS/MS techniques for measuring LTB(4) concentrations in EBC have been developed and are suitable for an accurate quantitative assessment of its concentrations in EBC. LC/MS/MS for other eicosanoids including 8-isoprostane, a marker of oxidative stress, and cysteinyl-LTs have been developed. This article, mainly focused on LTB(4), presents the analytical aspects of the LC/MS/MS techniques for measuring LTB(4) and 8-isoprostane in EBC, provides examples of their application to the assessment of airway inflammation in patients with asthma and other respiratory diseases, and discusses their potential utility for non-invasive monitoring of drug therapy.
| Autori: | |
| Titolo: | LC/MS/MS analysis of leukotriene B4 in exhaled breath condensate for assessing lung inflammation. |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jchromb.2009.01.036 |
| Data di pubblicazione: | 2009 |
| Abstract: | Leukotriene (LT) B(4) is a potent inflammatory lipid mediator that has been involved in the pathophysiology of respiratory diseases including asthma. Exhaled breath condensate (EBC) is a non-invasive method to sample secretions from the airways. LC/MS/MS techniques for measuring LTB(4) concentrations in EBC have been developed and are suitable for an accurate quantitative assessment of its concentrations in EBC. LC/MS/MS for other eicosanoids including 8-isoprostane, a marker of oxidative stress, and cysteinyl-LTs have been developed. This article, mainly focused on LTB(4), presents the analytical aspects of the LC/MS/MS techniques for measuring LTB(4) and 8-isoprostane in EBC, provides examples of their application to the assessment of airway inflammation in patients with asthma and other respiratory diseases, and discusses their potential utility for non-invasive monitoring of drug therapy. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Montuschi, P., LC/MS/MS analysis of leukotriene B4 in exhaled breath condensate for assessing lung inflammation., <<JOURNAL OF CHROMATOGRAPHY. B>>, 2009; 877 (Maggio): 1272-1280. [doi:10.1016/j.jchromb.2009.01.036] [http://hdl.handle.net/10807/31061] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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