Background: According to current guidelines, patients with heart valve disease should be followed by Heart Valve Clinics (HVCs). Regular quality analysis is a major prerequisite of an HVC’s program, but few data have been reported so far. Methods: We retrospectively collected patients with isolated, native aortic valve stenosis who had been visited in our HVC at least once between 2021 and 2024. For each outpatient visit, symptoms, physical examination, echocardiographic data, complementary tests, and indications were acquired. Also, adverse events (hospitalization, unplanned procedures, and death) were retrieved. Results: A total of 320 patients were included. Mean visits/patient ratio was 1.2. At the first visit, 69.7% already had severe aortic stenosis, and severe symptoms (NYHA ≥ III) were evident in 24.4%. In addition, 26.5%, 59.1%, 12.8%, and 1.6% were in Généreux stage I, II, III, and IV, respectively. Overall, 197 (78.5%) and 54 (21.5%) patients received an indication for transcatheter AVR and surgical AVR, respectively. AVR-free survival was 46%, 23%, and 6% at 6, 12, and 24 months, respectively (mean 8.8 months CI95% 7.7–9.9). Adverse event-free survival was 97.2%, 95.5%, and 85% at 3, 6, and 12 months, respectively. Conclusions: Patients referred to our HVC already had an advanced disease with cardiac damage. Transcatheter AVR was mostly indicated, and it showed excellent short-term results. A low rate of adverse events was seen among patients in follow-up, but the odds of receiving AVR were high and driven by Généreux’s stage. Despite these favorable results, further efforts to sensitize earlier patient referral should be made.

Cammertoni, F., Pavone, N., Bruno, P., Di Giammarco, G., Burzotta, F., Romagnoli, E., Lombardo, A., Graziani, F., Nesta, M., Grandinetti, M., D'Avino, S., Marcolini, A., Cutrone, G., D'Acierno, E. M., Panzera, R., Mazzenga, G., Montesano, M., Massetti, M., Management, Flow, and Outcomes of Patients with Aortic Stenosis Followed by a Heart Valve Clinic: The Untold "Behind the Scene" from a High-Volume, Real-World Experience, <<JOURNAL OF CLINICAL MEDICINE>>, 2025; 14 (1): N/A-N/A. [doi:10.3390/jcm14010267] [https://hdl.handle.net/10807/306681]

Management, Flow, and Outcomes of Patients with Aortic Stenosis Followed by a Heart Valve Clinic: The Untold "Behind the Scene" from a High-Volume, Real-World Experience

Cammertoni, Federico;Pavone, Natalia;Bruno, Piergiorgio;Burzotta, Francesco;Romagnoli, Enrico;Lombardo, Antonella;Graziani, Francesca;Nesta, Marialisa;Cutrone, Gessica;D'Acierno, Edoardo Maria;Panzera, Rudy;Mazzenga, Gabriele;Montesano, Marco;Massetti, Massimo
2025

Abstract

Background: According to current guidelines, patients with heart valve disease should be followed by Heart Valve Clinics (HVCs). Regular quality analysis is a major prerequisite of an HVC’s program, but few data have been reported so far. Methods: We retrospectively collected patients with isolated, native aortic valve stenosis who had been visited in our HVC at least once between 2021 and 2024. For each outpatient visit, symptoms, physical examination, echocardiographic data, complementary tests, and indications were acquired. Also, adverse events (hospitalization, unplanned procedures, and death) were retrieved. Results: A total of 320 patients were included. Mean visits/patient ratio was 1.2. At the first visit, 69.7% already had severe aortic stenosis, and severe symptoms (NYHA ≥ III) were evident in 24.4%. In addition, 26.5%, 59.1%, 12.8%, and 1.6% were in Généreux stage I, II, III, and IV, respectively. Overall, 197 (78.5%) and 54 (21.5%) patients received an indication for transcatheter AVR and surgical AVR, respectively. AVR-free survival was 46%, 23%, and 6% at 6, 12, and 24 months, respectively (mean 8.8 months CI95% 7.7–9.9). Adverse event-free survival was 97.2%, 95.5%, and 85% at 3, 6, and 12 months, respectively. Conclusions: Patients referred to our HVC already had an advanced disease with cardiac damage. Transcatheter AVR was mostly indicated, and it showed excellent short-term results. A low rate of adverse events was seen among patients in follow-up, but the odds of receiving AVR were high and driven by Généreux’s stage. Despite these favorable results, further efforts to sensitize earlier patient referral should be made.
2025
Inglese
Cammertoni, F., Pavone, N., Bruno, P., Di Giammarco, G., Burzotta, F., Romagnoli, E., Lombardo, A., Graziani, F., Nesta, M., Grandinetti, M., D'Avino, S., Marcolini, A., Cutrone, G., D'Acierno, E. M., Panzera, R., Mazzenga, G., Montesano, M., Massetti, M., Management, Flow, and Outcomes of Patients with Aortic Stenosis Followed by a Heart Valve Clinic: The Untold "Behind the Scene" from a High-Volume, Real-World Experience, <<JOURNAL OF CLINICAL MEDICINE>>, 2025; 14 (1): N/A-N/A. [doi:10.3390/jcm14010267] [https://hdl.handle.net/10807/306681]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/306681
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