To cite this article: Dello Iacono I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli Sopo S. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial. Pediatr Allergy Immunol 2012: 00. ABSTRACT: Background:  Treatment of severe egg allergy is avoidance of hen's egg (HE) and carrying self-injectable epinephrine. Specific oral tolerance induction (SOTI) seems a promising alternative treatment. However, some aspects of SOTI are still considered experimental. Methods:  We evaluated the efficacy and safety of an original 6-month SOTI protocol in children with very severe HE allergy using raw HE emulsion. Twenty children (age range: 5-11 yr) were randomized equally into a SOTI treatment group and a control group. The treatment group started SOTI and underwent a second challenge 6 months later. Control children were kept on an egg-free diet for 6 months and then underwent a second challenge. Results:  After 6 months, 9/10 children of the SOTI group (90%) achieved partial tolerance (at least 10 ml, but <40 ml of raw HE emulsion, in a single dose) and 1 (10%) was able to tolerate only 5 ml (no tolerance). After 6 months, nine control children tested positive to the second challenge at a dose ≤0.9 ml of raw HE emulsion, and one reacted to 1.8 ml (SOTI vs. control group p < 0.0001). All children in the SOTI group had side effects, but no child had a grade 5 reaction according to the Sampson grading. Conclusion:  Six months of SOTI with raw HE emulsion resulted in partial tolerance, with regular intake, in a significant percentage of children with severe egg allergy.

Dello Iacovo, I., Tripodi, S., Calvani, M., Panetta, V., Verga, M. C., Miceli Sopo, S., Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial, <<PEDIATRIC ALLERGY AND IMMUNOLOGY>>, 2012; 24 (1): 66-74. [doi:10.1111/j.1399-3038.2012.01349.x] [http://hdl.handle.net/10807/30657]

Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial

Miceli Sopo, Stefano
2013

Abstract

To cite this article: Dello Iacono I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli Sopo S. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial. Pediatr Allergy Immunol 2012: 00. ABSTRACT: Background:  Treatment of severe egg allergy is avoidance of hen's egg (HE) and carrying self-injectable epinephrine. Specific oral tolerance induction (SOTI) seems a promising alternative treatment. However, some aspects of SOTI are still considered experimental. Methods:  We evaluated the efficacy and safety of an original 6-month SOTI protocol in children with very severe HE allergy using raw HE emulsion. Twenty children (age range: 5-11 yr) were randomized equally into a SOTI treatment group and a control group. The treatment group started SOTI and underwent a second challenge 6 months later. Control children were kept on an egg-free diet for 6 months and then underwent a second challenge. Results:  After 6 months, 9/10 children of the SOTI group (90%) achieved partial tolerance (at least 10 ml, but <40 ml of raw HE emulsion, in a single dose) and 1 (10%) was able to tolerate only 5 ml (no tolerance). After 6 months, nine control children tested positive to the second challenge at a dose ≤0.9 ml of raw HE emulsion, and one reacted to 1.8 ml (SOTI vs. control group p < 0.0001). All children in the SOTI group had side effects, but no child had a grade 5 reaction according to the Sampson grading. Conclusion:  Six months of SOTI with raw HE emulsion resulted in partial tolerance, with regular intake, in a significant percentage of children with severe egg allergy.
2013
Inglese
Dello Iacovo, I., Tripodi, S., Calvani, M., Panetta, V., Verga, M. C., Miceli Sopo, S., Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial, <<PEDIATRIC ALLERGY AND IMMUNOLOGY>>, 2012; 24 (1): 66-74. [doi:10.1111/j.1399-3038.2012.01349.x] [http://hdl.handle.net/10807/30657]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/30657
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