The coagulation and fibrinolytic systems safeguard the patency of the vasculature and the surrounding tissue. Regulation of these systems is accomplished by various mechanisms involving cellular responses, flow, and protein–protein interactions. Thrombin activatable fibrinolysis inhibitor (TAFI) is a fibrinolysis inhibitor, and its activation is sensitive to the dynamics of the coagulation system; it is one of the main intermediaries between coagulation and fibrinolysis. TAFI is a thrombin, thrombin/thrombomodulin and/or plasmin-activated enzyme that has greatly improved our understanding of the cross-regulation between coagulation and fibrinolysis, and its pathway modulates both the coagulation and the fibrinolytic system.
Biscetti, F., Glycosylation of thrombin activatable fibrinolysis inhibitor: Why is it so important?, <<CIRCULATION RESEARCH>>, 2008; 102 (3): 278-279. [doi:10.1161/CIRCRESAHA.107.170498] [https://hdl.handle.net/10807/305659]
Glycosylation of thrombin activatable fibrinolysis inhibitor: Why is it so important?
Biscetti, Federico
2008
Abstract
The coagulation and fibrinolytic systems safeguard the patency of the vasculature and the surrounding tissue. Regulation of these systems is accomplished by various mechanisms involving cellular responses, flow, and protein–protein interactions. Thrombin activatable fibrinolysis inhibitor (TAFI) is a fibrinolysis inhibitor, and its activation is sensitive to the dynamics of the coagulation system; it is one of the main intermediaries between coagulation and fibrinolysis. TAFI is a thrombin, thrombin/thrombomodulin and/or plasmin-activated enzyme that has greatly improved our understanding of the cross-regulation between coagulation and fibrinolysis, and its pathway modulates both the coagulation and the fibrinolytic system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.