Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and a public health problem. Several clinical studies have shown that copper (Cu) is involved in carcinogenesis, possibly via cuproptosis, a new form of programmed cell death, but the conclusions from published reports are inconsistent. This study aimed at evaluating the potential of Cu dysregulation as a CRC susceptibility factor. Methods: In this systematic review and meta-analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum Cu concentrations in CRC patients and controls from articles published till June 2023. The studies included reported measurements of serum/plasma/blood Cu levels. Meta-analyses were performed as well as study quality, heterogeneity, and small study effects were assessed. Based on a random effects model, summary standardized mean differences (SMDs) and the corresponding 95% confidence intervals (95% CIs) were applied to compare the levels of Cu between CRC patients and controls. Results: 26 studies with a pooled total of9628 participants and 2578 CRC cases were included. The pooled SMD was equal to 0.85 (95% CIs −0.44; 2.14) showing that the CRC patients had higher mean Cu levels than the control subjects, but the difference was not significant (p = 0.185) and the heterogeneity was very high, I2 = 97.9% (95% CIs: 97.5–98.3%; p < 0.001). Conclusion: The pooled results were inconclusive, likely due to discordant results and inaccuracy in reporting data of some studies; further research is needed to establish whether Cu dysregulation might contribute to the CRC risk and whether it might reflect different CRC grades.

Squitti, R., Pal, A., Dhar, A., Shamim, M. A., Ventriglia, M., Simonelli, I., Rani, I., Sharma, A., Rizzo, G., Tondolo, V., Goswami, K., Rongioletti, M., Serum copper status of patients with colorectal cancer: A systematic review and meta-analysis, <<JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY>>, 2024; 82 (mar): N/A-N/A. [doi:10.1016/j.jtemb.2023.127370] [https://hdl.handle.net/10807/305125]

Serum copper status of patients with colorectal cancer: A systematic review and meta-analysis

Rizzo, Gianluca;Tondolo, Vincenzo;
2024

Abstract

Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and a public health problem. Several clinical studies have shown that copper (Cu) is involved in carcinogenesis, possibly via cuproptosis, a new form of programmed cell death, but the conclusions from published reports are inconsistent. This study aimed at evaluating the potential of Cu dysregulation as a CRC susceptibility factor. Methods: In this systematic review and meta-analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum Cu concentrations in CRC patients and controls from articles published till June 2023. The studies included reported measurements of serum/plasma/blood Cu levels. Meta-analyses were performed as well as study quality, heterogeneity, and small study effects were assessed. Based on a random effects model, summary standardized mean differences (SMDs) and the corresponding 95% confidence intervals (95% CIs) were applied to compare the levels of Cu between CRC patients and controls. Results: 26 studies with a pooled total of9628 participants and 2578 CRC cases were included. The pooled SMD was equal to 0.85 (95% CIs −0.44; 2.14) showing that the CRC patients had higher mean Cu levels than the control subjects, but the difference was not significant (p = 0.185) and the heterogeneity was very high, I2 = 97.9% (95% CIs: 97.5–98.3%; p < 0.001). Conclusion: The pooled results were inconclusive, likely due to discordant results and inaccuracy in reporting data of some studies; further research is needed to establish whether Cu dysregulation might contribute to the CRC risk and whether it might reflect different CRC grades.
2024
Inglese
Squitti, R., Pal, A., Dhar, A., Shamim, M. A., Ventriglia, M., Simonelli, I., Rani, I., Sharma, A., Rizzo, G., Tondolo, V., Goswami, K., Rongioletti, M., Serum copper status of patients with colorectal cancer: A systematic review and meta-analysis, <<JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY>>, 2024; 82 (mar): N/A-N/A. [doi:10.1016/j.jtemb.2023.127370] [https://hdl.handle.net/10807/305125]
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