Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset.
Falso, S., Gessi, M., Marini, S., Benvenuto, R., Sabatelli, E., D'Amati, A., Marini, M., Evoli Stampanoni-B, A., Iorio, R., Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology, <<ANNALS OF NEUROLOGY>>, 2024; 96 (5): 1020-1025. [doi:10.1002/ana.27033] [https://hdl.handle.net/10807/304661]
Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology
Falso, Silvia;Gessi, Marco;Marini, Martina;Evoli Stampanoni-B, Amelia;Iorio, Raffaele
2024
Abstract
Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset.
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