The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.
Anpalakhan, S., Signori, A., Cortellini, A., Verzoni, E., Giusti, R., Aprile, G., Ermacora, P., Catino, A., Pipitone, S., Di Napoli, M., Scotti, V., Mazzoni, F., Guglielmini, P., Veccia, A., Maruzzo, M., Schinzari, G., Casadei, C., Grossi, F., Rizzo, M., Montesarchio, V., Verderame, F., Mencoboni, M., Zustovich, F., Fratino, L., Accettura, C., Cinieri, S., Tondini, C., Camerini, A., Banzi, M., Sorarù, M., Zucali, P., Vignani, F., Ricciardi, S., Russo, A., Cosenza, A., Di Maio, M., De Giorgi, U., Pignata, S., Giannarelli, D., Pinto, C., Buti, S., Fornarini, G., Rebuzzi, S., Rescigno, P., Addeo, A., Banna, G., Bersanelli, M., Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis, <<ISCIENCE>>, 2023; 26 (11): N/A-N/A. [doi:10.1016/j.isci.2023.107970] [https://hdl.handle.net/10807/304643]
Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis
Schinzari, Giovanni;Camerini, Andrea;
2023
Abstract
The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.
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