Three patients who presented with parkinsonian signs resulting from a focal midbrain lesion are reported. In all patients parkinsonian features occurred acutely and improved following acute challenge with apomorphine but not with levodopa. Remission of parkinsonian signs occurred spontaneously to a different degree. Inconsistent clinical response following administration of levodopa has been well documented in patients with focal midbrain lesions associated with parkinsonian signs; however, the efficacy of apomorphine has not been tested before. Anatomic or etiologic features do not allow us to predict in which cases parkinsonian signs secondary to a midbrain lesion would respond to levodopa or to dopamine agonists. A trial with apomorphine is warranted in all such cases.

Albanese, A., Moro, E., Apomorphine and levodopa challenge in patients with a focal midbrain lesion, <<MOVEMENT DISORDERS>>, 1999; (14): 269-275 [http://hdl.handle.net/10807/30419]

Apomorphine and levodopa challenge in patients with a focal midbrain lesion

Albanese, Alberto;
1999

Abstract

Three patients who presented with parkinsonian signs resulting from a focal midbrain lesion are reported. In all patients parkinsonian features occurred acutely and improved following acute challenge with apomorphine but not with levodopa. Remission of parkinsonian signs occurred spontaneously to a different degree. Inconsistent clinical response following administration of levodopa has been well documented in patients with focal midbrain lesions associated with parkinsonian signs; however, the efficacy of apomorphine has not been tested before. Anatomic or etiologic features do not allow us to predict in which cases parkinsonian signs secondary to a midbrain lesion would respond to levodopa or to dopamine agonists. A trial with apomorphine is warranted in all such cases.
Inglese
Albanese, A., Moro, E., Apomorphine and levodopa challenge in patients with a focal midbrain lesion, <<MOVEMENT DISORDERS>>, 1999; (14): 269-275 [http://hdl.handle.net/10807/30419]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/30419
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