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EnglishThree patients who presented with parkinsonian signs resulting from a focal midbrain lesion are reported. In all patients parkinsonian features occurred acutely and improved following acute challenge with apomorphine but not with levodopa. Remission of parkinsonian signs occurred spontaneously to a different degree. Inconsistent clinical response following administration of levodopa has been well documented in patients with focal midbrain lesions associated with parkinsonian signs; however, the efficacy of apomorphine has not been tested before. Anatomic or etiologic features do not allow us to predict in which cases parkinsonian signs secondary to a midbrain lesion would respond to levodopa or to dopamine agonists. A trial with apomorphine is warranted in all such cases.
Albanese, A., Moro, E., Apomorphine and levodopa challenge in patients with a focal midbrain lesion, <<MOVEMENT DISORDERS>>, 1999; (14): 269-275 [http://hdl.handle.net/10807/30419]
| Autori: | |
| Titolo: | Apomorphine and levodopa challenge in patients with a focal midbrain lesion |
| Data di pubblicazione: | 1999 |
| Abstract: | Three patients who presented with parkinsonian signs resulting from a focal midbrain lesion are reported. In all patients parkinsonian features occurred acutely and improved following acute challenge with apomorphine but not with levodopa. Remission of parkinsonian signs occurred spontaneously to a different degree. Inconsistent clinical response following administration of levodopa has been well documented in patients with focal midbrain lesions associated with parkinsonian signs; however, the efficacy of apomorphine has not been tested before. Anatomic or etiologic features do not allow us to predict in which cases parkinsonian signs secondary to a midbrain lesion would respond to levodopa or to dopamine agonists. A trial with apomorphine is warranted in all such cases. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Albanese, A., Moro, E., Apomorphine and levodopa challenge in patients with a focal midbrain lesion, <<MOVEMENT DISORDERS>>, 1999; (14): 269-275 [http://hdl.handle.net/10807/30419] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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