The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.

Carciero, L., Di Giuseppe, G., Di Piazza, E., Parand, E., Soldovieri, L., Ciccarelli, G., Brunetti, M., Gasbarrini, A., Nista, E. C., Pani, G., Pontecorvi, A., Giaccari, A., Mezza, T., The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes, <<DIABETES RESEARCH AND CLINICAL PRACTICE>>, 2024; 216 (n/a): N/A-N/A. [doi:10.1016/j.diabres.2024.111837] [https://hdl.handle.net/10807/303685]

The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

Di Giuseppe, Gianfranco;Soldovieri, Laura;Ciccarelli, Gea;Brunetti, Michela;Gasbarrini, Antonio;Nista, Enrico Celestino;Pani, Giovambattista;Pontecorvi, Alfredo;Giaccari, Andrea;Mezza, Teresa
2024

Abstract

The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.
2024
Inglese
Carciero, L., Di Giuseppe, G., Di Piazza, E., Parand, E., Soldovieri, L., Ciccarelli, G., Brunetti, M., Gasbarrini, A., Nista, E. C., Pani, G., Pontecorvi, A., Giaccari, A., Mezza, T., The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes, <<DIABETES RESEARCH AND CLINICAL PRACTICE>>, 2024; 216 (n/a): N/A-N/A. [doi:10.1016/j.diabres.2024.111837] [https://hdl.handle.net/10807/303685]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/303685
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